Tadalafil was introduced on the American market in December 2003, is named “The weekend pill” for the long lasting effect that has on the blood vessels responsible for the male erection. Tadalafil effect can last up to 36 hours; the reason for the long effects on blood vessels is due to the much larger power of Tadalafil to maintain its inhibitory power on the PDE 5 enzyme.
This male enhancer is on the market in three dosage sizes; five, ten and twenty grams per tablet and is a yellow, film coated, almond shaped pill. The larger dosage size of Tadalafil (twenty grams) is comparable in power, to a hundred grams Sildenafil tablet, better known as Viagra. The way that Tadalafil works is by inhibiting the PDE 5 causing the enlargement of the blood vessels that regulates the inflow of the blood, and shrinking the vessel that evacuates the blood flow, causing a larger quantity of blood to enlarge the muscle tissue causing the erection.
The erection with Tadalafil lasts longer than with other PDE 5 enzyme inhibitors because of the higher content of inhibitors compared to the other two leading men enhancement pills: Viagra and Levitra.
The best feature of this male enhancer is the length of the active effects of the enzyme inhibitors that allow the consumer to decide the best time for the performance, having the tablet such a long lasting ability to influence the blood flow.
The effect of Tadalafil is detectable after only thirty minutes after taking the pill, and it has proven not to diminish the effects on the PDE 5 enzymes over time. The drug was tested on more than 4000 subjects, and was carried out by both National, and International panels. The US based statistic, that took place in five research center with placebo-controlled trials, took in consideration studies involving over eleven hundred subjects with an average age of 59, and aimed at establish the safety and effectiveness level of the product.
The two trials done in international testing laboratories took place using the same standards and carried out on subjects in the same age and physical conditions and they produced the same results.
The results of the five International, and two US based studies, have also demonstrated that, during the period of the trial, the effect of Tadalafil did not decrease, in subjects suffering from various severity levels of ED, hypertension, diabetes mellitus, and other cardiovascular diseases.
The dosage used for the researches ranged from the lower of 2.5 grams, to the more potent of the dosages available; 20 grams.
On the bases of the results of these research trials, Tadalafil received the FDA approval in December 2003. Tadalafil does not require any particular precaution for its storage, it needs to be stored out of childrens reach and stored at room temperature avoiding exposure to heat or humidity.
As with every other smooth muscle relaxants, no other drug containing nitrates should be taken when taking Tadalafil. More studies have showed that Tadalafil agents, act as inhibitors 10,000 more powerfully on the PDE 5 enzyme, than on all other enzymes present in the body, focusing its effect in great majority on the specific enzymes that causes Erectile Dysfunction.